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Who plays tonight? Week 6 college football Friday games TV channel, betting odds
Matthew Glenesk, USA TODAY October 3, 2025 at 5:26 PM
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There are five games Friday night in Week 6 of the college football season, with No. 23 BYU hosting West Virginia in Big 12 action the headliner.
But don't overlook a key matchup in Conference USA as Western Kentucky (4-1, 2-0) takes on Delaware (3-1, 1-0) in a key early-season league clash.
Here's the rest of Friday night's schedule with TV info and betting odds for each game.
College football Week 6 picks: Predictions for Top 25 games include Miami-FSU
College Football Week 6: The six games you can't miss include SEC, ACC rivalries
College football Week 6 Friday night schedule
Odds courtesy of BetMGM.
Charlotte vs South Florida football betting odds, TV channel -
Time: 7 p.m.
TV: ESPN2
Betting odds: South Florida (-28), O/U 55.5
Stream Week 6 of college football with Fubo (free trial)
Western Kentucky vs Delaware football betting odds, TV channel -
Time: 7 p.m.
TV: CBS Sports Network
Betting odds: Delaware (-2.5), O/U 61.5
New Mexico vs San Jose State football betting odds, TV channel -
Time: 10 p.m.
TV: FS1
Betting odds: San Jose State (-2.5), O/U 58.5
West Virginia vs BYU football betting odds, TV channel -
Time: 10:30 p.m.
TV: ESPN
Betting odds: BYU (-20.5); O/U 46.5
Prediction: BYU 41, West Virginia 13
The Mountaineers have looked stunningly bad in their first season of Rich Rodriguez's second go-around at the school, with their two Big 12 losses coming by a combined 65 points. Things won't get any easier against a tough, physical Cougars team that will be playing at altitude. — Craig Meyer, USA TODAY
Colorado State vs San Diego State football betting odds, TV channel -
Time: 10:30 p.m.
TV: CBS Sports Network
Betting odds: San Diego State (-5.5); O/U 41.5
This article originally appeared on USA TODAY: Sports tonight: CFB Week 6 times, TV channel, betting odds, schedule
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